Acute Myocarditis after Pfizer-BioNTech COVID-19 m-RNA Vaccination

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Elena Grueva-Nastevska
Valentina Andova
Planinka Zafirovska
Ema Kandic
Ana Chelikikj
Elif Vrajnko
Simona Jovchevska
Oliver Busljetikj
Zhan Zimbakov
Igor M. Spiroski
Silvana Jovanova


BACKGROUND: Prosthetic mechanical valve endocarditis (PVE) can be manifested as early PVE (acquired perioperatively) and late PVE (resulting from infections unrelated to the valve operation). Causes of both are similar but are late PVE are more prone to less virulent microbes. PVE resulting with paravalvular abscess is confirmed through echocardiography (transthoracic or transesophageal), it results with a high mortality rate especially if it is not early recognized.

CASE PRESENTATION: We are presenting a patient with heart failure symptoms caused by PVE after Pfizer-BioNTech coronavirus disease-2019 (COVID-19) m-RNA vaccination.

CONCLUSION: The exact mechanism of myocarditis in young men who received the second dose of mRNA COVID-19 vaccine is not yet known. However, this is a rare complication and most people generally recover quickly requiring only supportive treatment. In contrast, the risk of developing myocarditis from the viral infection is much higher.


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Grueva-Nastevska E, Andova V, Zafirovska P, Kandic E, Chelikikj A, Vrajnko E, Jovchevska S, Busljetikj O, Zimbakov Z, Spiroski IM, Jovanova S. Acute Myocarditis after Pfizer-BioNTech COVID-19 m-RNA Vaccination. SEE J Cardiol [Internet]. 2022 Nov. 30 [cited 2024 Mar. 2];3(1):11-4. Available from:
General Cardiology


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